Please use this identifier to cite or link to this item:
http://ir.mu.ac.ke:8080/jspui/handle/123456789/1417
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ndede, Isaac | - |
dc.date.accessioned | 2018-08-14T07:18:13Z | - |
dc.date.available | 2018-08-14T07:18:13Z | - |
dc.date.issued | 2008-05 | - |
dc.identifier.uri | http://ir.mu.ac.ke:8080/xmlui/handle/123456789/1417 | - |
dc.description.abstract | Background: A few people remain persistently exposure to HIV - 1 via sexual or systemic seronegative despite frequent routes. The mechanism of this apparent resistance to HIV - 1 infection is not clearly known. Objective: This study assessed cellular immune responses to HIV - 1 in terms of CD8+,CD4+T, CD56+/16+ and CD19+ cell proliferation by Th1ITh2 cytokine expression concordant positive/negative in heterosexual and function as indicated HIV - 1 discordant and couples. Design: Cross sectional prospective study. Study population: Sixty-six (66) subjects comprising of discordant, concordant positive (untreated with CD4 ~ 250-cells/J.ll) and concordant negative controls were recruited from western Kenya. Method: Blood samples were drawn in EDTA vacuitaners antecubital vein. Complete by venipuncture blood count (CBC), lymphocyte phenotypes cytokine levels analysis were done to assess cellular and functional responsesto HIV - 1 using Beckman" coulter and Facscalibur" of and immune respectively. Results: Discordant uninfected females had mean, cell s/ul,, CD4+ (727), CD8+ (1035), CD56+/16+ (295) CD19+ (298) and ThlTs (1.4) compared to concordant negative females CD4+ (923) CD8+ (591), CD56+/16+ (857), CD19+ (352) and ThlTs (1.6) respectively. Discordant index females had higher %CD4 and ThlTs than concordant positive females 28.0%, 18.3% p=0.024, and 0.7, 0.4 p=0.016 respectively but lower CD8+ 711.0, 1131 p=0.007. Female partners had higher CD19+counts and % than index females and males. Mean lymphocyte, were positively correlated with HIV - 1 RNA and cytokine ceII s/ul., levels (r=0.371, r=0.800)in discordant individuals but negatively correlated in concordant positive participants. Conclusion: These findings indicate CD4+, CD8+, CD56+/16+ and CD19+ immune specific and non-specific responses to chronic exposure to HIV - 1 and possible immunological protection among discordant individuals. Studies using HIV -1 specific antigen and lymphocytes targets, in larger sample sized study is recommended. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Moi University | en_US |
dc.subject | HIV - 1 | en_US |
dc.subject | Immune Responses | en_US |
dc.title | Immune Responses In HIV - 1 Discordant Couples in Western Kenya | en_US |
dc.type | Thesis | en_US |
Appears in Collections: | School of Medicine |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Ndede Isaac 2008.pdf | 1.09 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.