http://ir.mu.ac.ke:8080/jspui/handle/123456789/9 2026-04-20T09:07:48Z http://ir.mu.ac.ke:8080/jspui/handle/123456789/9278 Title: PA-364 Knowledge and reporting of adverse events following childhood immunization among health workers and caregivers at Mengo hospital, Kampala Authors: Watyaba, Benjamin; Knezevic, Ivana; Adong, Florence; Kewaza, Faith; Bazira, Henry; Nankonyoli, Oliver; Malande, Ombeva; Kikaire, Bernard Abstract: Although all vaccines used in National Immunization Programmes are safe and effective, no vaccine is completely risk-free and adverse events occasionally occur after an immunization. Failure to report adverse events following immunization (AEFI) can lead to death and misconceptions about vaccine safety hence vaccine hesitancy. Alleged vaccine quality and safety issues must be dealt with rapidly and effectively. This study assessed level of knowledge and reporting of AEFI among healthcare workers and caregivers at Mengo Hospital, Kampala. 2023-12-01T00:00:00Z http://ir.mu.ac.ke:8080/jspui/handle/123456789/8412 Title: EP411/#1297 Prognostic factors associated with ultra-high-risk gestational trophoblastic neoplasia Authors: Philippe, Poli; Itsura, Peter; Orang'o, Elkanah Omenge; Tonui, Philiph; Kosgei, Wycliffe; Aruasa, Wilson Kipkirui; Mogeni, Richard Abstract: Introduction The aim of this study was to determine the prognostic factors associated with ultra-high-risk gestational trophoblastic neoplasia (UHR-GTN). Globally, women diagnosed with UHR-GTN have poor outcomes, despite the disease being the most curable gynecological malignancy. Methods This was a hospital-based retrospective study that was carried out at Moi Teaching and referral hospital from 2017 to 2023. The prognostic factors analyzed included patients, treatment, and disease factors. Results A total of 14 patients with UHR-GTN had their medical records reviewed. There was a 50% mortality rate. Mortality was higher among patients aged < 40 years old [85.7% vs 14.3%, p=0.23]. A high mortality rate was reported among women with anemia (100%) and septicemia (42.9%). Most patients with an initial ß-hCG of > 1,000,000 died from the disease [85.7% vs 14.3%, p=1.00]. Mortality from patients with liver and brain metastases was equally reported as 42.9% [p=0.56]. Death among those with more than 3 site metastases was 71.4% [p=0.46]. Mortality among those with more than 3 cm metastasis lesions size was 85.7% [p=0.10]. The mortality rate among those who received multimodality treatment was high [57.1% vs 42.9%, p=1.0]. A delay of ≥7 days in initiating and continuing treatment was not statistically associated with mortality [85.7%, p=0.10] and [71.4%, p=1.00], respectively. Conclusion/Implications The prognosis of UHR-GTN is poor. The age < 40 years old, anemia, septicemia, and initial ß-hCG level ≥1 million, the number and size of metastatic lesions were not statistically associated with mortality; however, there were reported to have high mortality.View this table: • View inline • View popup • Download powerpoint Abstract EP411/#1297 Table 1 Association between Mortality and socio-demographics and clinical characteristics obstetrics (n = 14) View this table: • View inline • View popup • Download powerpoint Abstract EP411/#1297 Table 2 Association between Mortality with patient, disease, and treatment factors (n = 14) 2023-11-01T00:00:00Z http://ir.mu.ac.ke:8080/jspui/handle/123456789/7226 Title: EP338/#105 Epidemiological profile and clinico-pathological features of pediatric gynecological cancers at moi teaching & referral hospital, Kenya Authors: Mburu, Anisa; Itsura, Peter; Omenge, Elkanah; Tonui, Philliph; Odongo, Elly; Shaffi, Afrin; Covens, Allan; Rosen, Barry Abstract: Objectives The main pediatric (0–18 years) gynecologic cancers include stromal carcinomas (juvenile granulose cell tumors and Sertoli-Leydig cell tumors), genital rhabdomyosarcomas and ovarian germ cell. Outcomes depend on time of diagnosis, stage, tumor type and treatment which can have long-term effects on the reproductive career of these patients. This study seeks to analyze the trends in clinical-pathologic presentation, treatment and outcomes in the cases seen at our facility. This is the first paper identifying these cancers published from sub-Saharan Africa. Methods Retrospective review of clinico-pathologic profiles and treatment outcomes of pediatric gynaecologic oncology patients managed at MTRH between 2010 and 2020. Data was abstracted from gynecologic oncology database and medical charts. Results Records of 40 patients were analyzed. Most, (92.5%, 37/40) of the patients were between 10 and 18 years. Ovarian germ cell tumors were the leading histological diagnosis in 72.5% (29/40) of the patients; with dysgerminomas being the commonest subtype seen in 12 of the 37 patients (32.4%). The patients received platinum-based chemotherapy in 70% of cases (28/40). There were 14 deaths among the 40 patients (35%) Conclusions Surgery remains the main stay of treatment and fertility-sparing surgery with or without adjuvant platinum-based chemotherapy are the standard of care with excellent prognosis following early detection and treatment initiation. LMICs face several challenges in access to quality care and that affects survival of these patients. Due to its commonality, ovarian germ cell cancers warrant a high index of suspicion amongst primary care providers attending to adnexal masses in this age group. 2022-01-01T00:00:00Z http://ir.mu.ac.ke:8080/jspui/handle/123456789/7196 Title: Cryotherapy and LEEP are effective treatment for CIN Lesions in HIV+ and HIV- women in Western Kenya Authors: Orang'o, Omenge; Mehta, Naaman; Mwangi, Ann; Omodi, Victor; Liu, Tao; Sang, Edwin; Tonui, Philip Abstract: Cervical cancer is the third most common cancer worldwide and the most common cancer among Kenyan women, with an age-standardized incidence rate of 33.8% in 2018. Cervical intraepithelial neoplasia (CIN) caused by human papillomavirus (HPV) in HIV+ women is over twice as likely to progress in severity compared to HIV- women. Conflicting reports exist as to the efficacy of cryotherapy or loop electrosurgical excision procedure (LEEP) as treatment for CIN among HIV+ women. This study assesses the results of cryotherapy or LEEP for CIN among HIV+ compared to HIV- women in Western Kenya. 2022-01-01T00:00:00Z